At La Jolla Naturals, we believe in nature‑driven innovation. Our newest formulation, Sytromin®, brings together two scientifically advanced, clinically studied botanical extracts: Sytrinol® and Eriomin®. Each one carries distinct health benefits, and combined, they are designed to deliver a multi‑layered support system for metabolic wellness, cardiovascular health, inflammation regulation, and more. In this post, we’ll explore the science behind each ingredient, how they work individually, and why their combination in Sytromin may represent a meaningful step forward.
The Foundation: Understanding Sytrinol®
The ingredient Sytrinol® is a patented proprietary blend of primarily citrus polymethoxylated flavones (PMFs) and tocotrienols (a form of vitamin E family), developed to support cardiovascular and metabolic markers. (rejuvenation-science.com)
Key ingredients & mechanism
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The PMFs (notably tangeretin, nobiletin) are flavonoids naturally found in citrus peel that are highly methoxylated (which may enhance bioactivity). (rejuvenation-science.com)
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Tocotrienols (from palm oil or other natural sources) are analogues to vitamin E and have been studied for antioxidant and lipid‑modulating effects. (rejuvenation-science.com)
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Proposed mechanisms include: supporting healthy lipid production in the liver, modulating oxidative stress and inflammation, improving triglyceride and LDL cholesterol profiles, and possibly improving insulin sensitivity or fat‑metabolism pathways. (herbalpharmacist.com)
What the clinical research shows
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One widely cited study reported that in human subjects taking ~300 mg/day of Sytrinol® for 12 weeks, total cholesterol dropped up to ~30%, LDL cholesterol up to ~27% and triglycerides up to ~34%, compared to placebo. (rejuvenation-science.com)
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Sytrinol® has also been shown to reduce C‑reactive protein (CRP) and other markers of inflammation—in part because the flavonoids may inhibit the NF‑κB pathway. (rejuvenation-science.com)
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Additional studies suggest Sytrinol may have beneficial effects on insulin resistance in animal models (hamsters) fed high‑fructose diets, supporting the possibility of metabolic benefit beyond lipids. (rejuvenation-science.com)
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The manufacturer’s materials and independent sources note that Sytrinol® may strengthen capillaries, contribute to antioxidant protection of LDL (preventing LDL oxidation) and support overall heart‑health and circulatory health. (herbalpharmacist.com)
Why this matters
In today’s world, many adults struggle with subtle metabolic dysregulation: elevated triglycerides, borderline LDL/HDL ratios, insulin resistance, higher levels of systemic inflammation and oxidative stress. Sytrinol addresses several of these priority areas:
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By improving lipid profiles and reducing oxidative stress, it helps reduce burden on the cardiovascular system.
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By modulating inflammation (via flavonoids) it may help reduce the risk of downstream complications linked to cardiovascular and metabolic disease.
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By improving insulin sensitivity (in pre‑clinical studies) it hints at broader metabolic support, which is a key foundation for health and longevity.
In short: Sytrinol gives us a solid base for cardiovascular‑metabolic support.
The Complement: Understanding Eriomin®
Where Sytrinol® mainly supports lipid and circulatory health (and secondarily metabolic), Eriomin® is targeted more directly at glucose metabolism, inflammation, oxidative stress, and gut‑microbiome modulation. It is a patented citrus flavonoid blend (largely eriocitrin from lemon), with multiple human clinical trials behind it. (PMC)
Key ingredients & mechanism
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Eriomin® is composed primarily of eriocitrin (~70%), with smaller amounts of hesperidin (~5%), naringin (~4%) and didymin (~1%) as part of the blend. (ingredientsbynature.com)
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It targets the metabolic axis—especially around blood glucose levels, insulin resistance, the incretin hormone GLP‑1, oxidative stress and inflammation. For example, in one human trial (~12 weeks, 200 mg/day) it decreased fasting blood glucose by ~5%, HOMA‑IR (insulin resistance index) by ~11% and glucagon by ~13%. (PMC)
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It also increased GLP‑1 by ~17% in that same study. (ingredientsbynature.com)
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Another study found that supplementation with Eriomin® improved the gut microbiota in pre‑diabetic individuals: decreased undesirable Firmicutes/Lachnospiraceae, increased beneficial Ruminococcaceae, and reduced the genus Blautia (linked to hyperglycemia). (NutraIngredients.com)
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Eriomin® also improved antioxidant status: one study in older rats showed reductions in total oxidant status, oxidative stress index, and improvements in antioxidant enzyme activity (glutathione peroxidase, glutathione reductase) in liver and intestines. (MDPI)
What the clinical evidence suggests
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In the 26‑week crossover human trial (200 mg/day), Eriomin® reduced fasting blood glucose by ~5%, HOMA‑IR by ~11%, IL‑6 (inflammatory marker) by ~14%, TNF‑α by ~20%. (PMC)
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Importantly, the microbiota study shows that Eriomin’s benefits may go beyond simply “lowering blood sugar” — by improving gut health and inflammation, which underpin many metabolic disorders. (Nutraceutical Business Review)
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The anti‑inflammatory and antioxidant data suggest that Eriomin® is positioned not just as a glucose support tool, but as a multi‑functional metabolic wellness ingredient (addressing glycemia, inflammation, oxidative stress, gut health).
Why this matters
Glucose dysregulation, insulin resistance, and metabolic inflammation are at the heart of many chronic conditions—from type 2 diabetes, to cardiovascular disease, to non‑alcoholic fatty liver disease and beyond. By supporting better glucose metabolism, increasing GLP‑1, reducing inflammation and oxidative stress, and improving gut‑microbiome balance, Eriomin helps tackle the root of metabolic breakdown rather than just one marker.
In other words: Eriomin provides the complementary metabolic support which pairs well with cardiovascular/lipid support from Sytrinol.
Why Combining Sytrinol® + Eriomin® Makes Sense in Sytromin®
Now that we’ve laid out Sytrinol® (cardio‑metabolic/lipid/oxidative) and Eriomin® (glucose/incretin/inflammation/gut) individually, let’s examine why their combination offers an upgraded formulation for holistic metabolic & cardiovascular wellness.
1. A Full Spectrum Approach
Many supplements address only one domain: cholesterol, or blood sugar, or inflammation. Sytromin® brings multiple domains together:
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Lipids & cardiovascular (via Sytrinol®)
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Glucose metabolism, insulin resistance, incretin support (via Eriomin®)
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Inflammation, oxidative stress, gut‑health (via both)
By supporting both sides (lipids & glucose/metabolism) the formulation acknowledges that metabolic health isn’t siloed—dysregulation in one domain often spills over into others (e.g., insulin resistance contributes to dyslipidemia, inflammation drives vascular damage). This synergy is central.
2. Cross‑Support & Synergistic Mechanisms
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Sytrinol® reduces oxidative stress and improves lipid profiles; oxidative stress is a driver of both cardiovascular disease and insulin resistance. By reducing oxidative burden, Sytrinol® may enhance the metabolic environment in which Eriomin® supports glucose regulation.
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Eriomin®’s support of GLP‑1 and gut‑microbiome health may improve metabolic flexibility and reduce systemic inflammation — which in turn can lighten the load on cardiovascular systems (helping lipids, vascular health).
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Together, they may create a positive feedback loop: better glucose control → less metabolic inflammation → improved lipid/vascular health → less oxidative stress → better metabolic resilience.
3. Addressing the Root, Not Just the Symptoms
With many supplements you’ll see “blood sugar support” or “cholesterol formula”, but often not both in one. Sytromin® is designed to bridge that gap. For consumers who are serious about metabolic‑cardiovascular wellness (and who understand these are interconnected), Sytromin offers an “all‑in‑one” botanical blend.
4. Differentiation & Premium Positioning
By using two clinically studied, branded ingredients (Sytrinol® and Eriomin®) rather than generic herbs or broad claims, Sytromin® can stand out in the crowded supplement market. For discerning consumers (in La Jolla and beyond) who look for science behind the label, this combination provides unique value.
5. Complementary Safety & Tolerability Profiles
While both ingredients are botanical and well‑tolerated in studies, combining them allows for dose optimization (each at a clinically validated dose) rather than pushing one ingredient to extremes.
Behind the Formulation: What We Did at La Jolla Naturals
When our formulation team sat down to design Sytromin®, we considered these guiding principles:
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Clinical dose translation – We reviewed the clinical trials for Sytrinol® (300 mg/day in many studies) and Eriomin® (200 mg/day in trials) and selected doses aligned with those benchmarks (while keeping overall capsule size, excipients, and quality control in premium tier).
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Ingredient sourcing & transparency – Both Sytrinol® and Eriomin® are standardized patented botanical blends with documented human clinical trials. We selected ingredients that deliver the branded potency and are third‑party tested.
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Holistic wellness positioning – Rather than hear “take for cholesterol” or “take for sugar”, we positioned Sytromin® for “Metabolic & cardiovascular wellness support” to appeal to consumers who are proactive about total health.
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Education & compliance – We built the label and educational materials to explain the synergy (“lipid support + glucose/inflammation support + antioxidant/gut support”) so that consumers understand the logic, not just the marketing.
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Quality & form factor – Because La Jolla Naturals stands for premium, we ensured Sytromin® is manufactured in a GMP facility, uses clean ingredients, minimal fillers, and packaging that reflects our coastal La Jolla inspiration (sun, sea, active healthy lifestyle).
Consumer Benefits: What Users Can Expect
While individual responses vary (and botanical supplements are not intended to diagnose, treat or cure disease), here’s a summary of the benefits consumers may experience with consistent use of Sytromin® (with healthy diet & lifestyle support):
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Support for healthy cholesterol and lipid profiles: including total cholesterol, LDL, triglycerides, and improved LDL:HDL ratio (via Sytrinol®).
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Support for healthy fasting blood glucose, insulin resistance indices, increased GLP‑1 incretin response, improved metabolic flexibility (via Eriomin®).
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Reduced markers of systemic inflammation and oxidative stress (via both ingredients).
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Improved gut‑microbiome parameters tied to metabolic health (via Eriomin®).
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Better overall metabolic/vascular resilience—meaning less metabolic drag, more stable energy, support for longer‑term wellness.
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Peace of mind of using quality, clinically studied ingredients in one product.
Important Considerations & Usage
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Lifestyle first: Supplementation is not a substitute for a healthy diet, regular exercise (especially cardio & strength training), adequate sleep, and stress management. Sytromin® supports your wellness efforts — it doesn’t replace them.
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Dosage: Follow the label instructions as provided by La Jolla Naturals (for example, “Take 2 capsules daily with a meal” or as directed).
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Medical supervision: If you are taking prescription medication (for blood sugar, lipids, or other cardiovascular/metabolic conditions), or you are pregnant/nursing, please consult your healthcare practitioner before starting any new supplement. Botanical extracts can interact with medications or underlying conditions.
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Patience & consistency: Many of the clinical studies for the ingredients were over 12 weeks (3 months) or more, so expect benefits to accrue with long‑term consistent use rather than overnight.
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Complementary habits: Because the formulation supports metabolic and cardiovascular health, pair with habits that support those domains: heart‑healthy diet (lean protein, vegetables, healthy fats, whole grains), regular aerobic and resistance exercise, minimizing ultra‑processed carbohydrates and refined sugars, maintaining healthy weight or body composition, managing stress, avoiding smoking, and getting adequate sleep.
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Monitoring: Because the product supports lipid and glucose systems, you may wish to monitor markers (fasting lipid panel, fasting glucose/insulin, HbA1c, inflammatory markers) with your healthcare provider to see how your body is responding over time.
Real‑World Use Case: Who This Might Be For
Sytromin® is well suited for adults who are proactive about their health and wellness and who may have one or more of the following characteristics:
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Want to support healthy blood sugar and metabolic flexibility (especially if diet/lifestyle sometimes fluctates)
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Want to support healthy cholesterol, triglycerides, LDL/HDL ratio (or want to be proactive even before major markers become problematic)
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Are looking for a botanically driven, premium supplement rather than starting immediately on pharmaceutical interventions (under doctor supervision)
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Want a comprehensive approach rather than “one supplement for sugar” and another for “cholesterol”
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Are committed to lifestyle habits (diet, exercise, sleep) and want a supplement that amplifies their efforts with high‑quality ingredients.
The Science Today & What’s Next
Both Sytrinol® and Eriomin® are backed by human clinical trials. That said, it's worth noting:
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While some studies for Sytrinol® and Eriomin® show promising results, science is always evolving and long‑term, large‑scale trials are still limited.
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Botanical supplements are not substitutes for medications when those are needed. For example, if you have diagnosed hyperlipidemia or diabetes, you must work with your doctor to determine appropriate pharmaceutical or lifestyle strategies.
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The combination of Sytrinol® + Eriomin® in one product has not yet been independently studied in a large randomized clinical trial (to my knowledge at this time). Therefore, while the rationale for synergy is strong, the exact combined effect in humans remains to be fully validated.
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We (at La Jolla Naturals) will continue to monitor emerging research, update our formulations and transparently share data with our customers.
That said, the evidence today is encouraging:
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Eriomin® reduces fasting blood glucose (~5%), improves GLP‑1, lowers insulin resistance and inflammatory markers.
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Sytrinol® reduces total cholesterol (~30%), LDL (~27%), triglycerides (~30‑34%) in human studies.
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Both carry antioxidant and anti‑inflammatory effects, which supports the notion of combined benefit in metabolic & cardiovascular domains.
Making Sytromin® Part of Your Wellness Routine
Here are some tips to maximize your results when using Sytromin®:
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Take it daily: Consistency matters. For best results, take Sytromin® every day (with or after a meal, depending on the label) for at least 12 weeks.
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Pair with a balanced diet: Emphasise whole foods: colorful vegetables, lean proteins (fish, poultry, legumes), healthy fats (olive oil, nuts, seeds), limited refined carbs and sugars.
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Move your body: Engage in both aerobic exercise (walking, jogging, cycling) and resistance training (weights, body‑weight). Exercise enhances insulin sensitivity, cardiovascular health and metabolic flexibility.
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Sleep & stress management: Poor sleep and chronic stress undermine metabolic health and cardiovascular resilience. Aim for 7‑9 hours of quality sleep and mindfulness/relaxation practices.
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Periodic monitoring: Consider working with your healthcare provider to track outcomes (fasting lipids, HbA1c or fasting glucose/insulin, CRP or other inflammation markers) so you can see the impact of your efforts including supplementation.
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Lifestyle mindset: Think of Sytromin® as part of an ecosystem of wellness — not a shortcut. Supplements amplify good behaviour; they don’t replace it.
Final Thoughts
In a world of one‑size‑fits‑all supplements, Sytromin® by La Jolla Naturals stands out by combining two rigorously studied botanical extracts—Sytrinol® and Eriomin®—to deliver multi‑domain support across metabolic, cardiovascular, inflammatory and oxidative pathways. We’re excited about this formulation because it reflects our belief that true wellness requires thoughtful integration: leveraging high‑quality ingredients, supporting both glucose and lipid health, and addressing underlying inflammation and oxidative stress rather than chasing individual numbers.
If you’re ready to support your metabolic and cardiovascular wellness on a deeper level — and you believe in premium botanical science — Sytromin® may be the natural complement to your wellness routine. As always, pair it with healthy diet, movement, sleep, stress‑management and regular check‑ins with your healthcare provider.
Why La Jolla Naturals?
Located in the coastal wellness hub of La Jolla, California, our brand is grounded in science‑based wellness, premium formulation, transparency and nature‑inspired living. We believe supplements should be smart, simple, effective, and beautifully designed. By combining Sytrinol® and Eriomin® into Sytromin®, we bring you a product that reflects this philosophy — one that bridges the gap between metabolic & cardiovascular support in a single, sophisticated blend.